An Italian greyhound owned by a gay couple has been infected with monkeypox in the first reported case passed from a human to their pet.

The French couple, involved in a non-monogamous relationship, are believed to have contracted monkeypox following sexual contact with other men. 

They said they noticed pustules on their dog's stomach. A PCR test later confirmed the pooch had contracted the virus.

The animal had shared a bed with the two men and had licked at least one of them before licking itself, according to the Lancet Medical Journal.

AFRICA CDC LOOKING TO OBTAIN MONKEYPOX VACCINES AS VIRUS SPREADS

Monkeypox color-enhanced micrograph

This image provided by the National Institute of Allergy and Infectious Diseases (NIAID) shows a colorized transmission electron micrograph of monkeypox particles (red) found within an infected cell (blue), cultured in the laboratory that was captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Md. (NIAID via AP)

Both men, ages 44 and 27, suffered from extensive ulcers and rashes since their cases were confirmed in June. And just 12 days after their symptoms began, the dog began showing signs it had contracted the virus.

The couple said they had been careful to keep their dog isolated from other pets or humans from the onset of their own symptoms.

Officials have said those infected with the virus should quarantine away from their pets to reduce transmission.

This is the first case in which a domesticated animal has been infected with monkeypox.

Vials of Monkeypox positive and negative results

Tubes labled "Monkeypox Virus" with positive and negative results pictured in this illustration taken May 23, 2022. (REUTERS/Dado Ruvic/Illustration)

"In endemic countries, only wild animals (rodents and primates) have been found to carry monkeypox virus," the Journal reported. "However, transmission of monkeypox virus in prairie dogs has been described in the USA and in captive primates in Europe that were in contact with imported infected animals."

The World Health Organization said the recent monkeypox outbreak is a global emergency. Nearly 100 countries have reported cases of monkeypox this year, and a dozen deaths have been linked to the virus.

WHO TO RENAME MONKEYPOX TO AVOID DISCRIMINATION AND STIGMATIZATION

Washington DC monkeypox vaccination

Workers sit outside of D.C. Health's first monkeypox vaccination clinic, which is administering the first Jynneos vaccine doses distributed in the U.S. capital, in Washington, U.S., June 28, 2022.  (REUTERS/Gavino Garay)

Monkeypox can spread through close, personal contact, including direct contact with monkeypox rash, scabs or body fluids from someone with the virus, or touching fabrics or objects used by someone with the virus. It can also be spread through sex, hugging, kissing, prolonged face-to-face contact or touching fabrics or objects during sex that were used by a person with monkeypox, according to the Center for Disease Control and Prevention.

CLICK HERE TO GET THE FOX NEWS APP

"It’s also possible for people to get monkeypox from infected animals, either by being scratched or bitten by the animal or by preparing or eating meat or using products from an infected animal," the CDC said on its website.