Skip to main content
SpringerLink
Log in

Preliminary assessment of radioiodinated fenoterol and reproterol as potential scintigraphic agents for lung imaging

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

Radioiodinated fenoterol and reproterol were prepared by electrophilic radioiodination reaction using chloramin-T as oxidizing agent with radiochemical yields of 97.7 ± 0.7 and 95.2 ± 0.3 %, respectively, and in vitro stability up to 72 h. Biodistribution study performed in male Albino Swiss mice showed maximum radioactivity accumulation in lungs tissue to the extent of 52 ± 1.03 and 50.6 ± 1.2 % ID/g at 15 and 30 min post injection (p.i.) for radioiodinated fenoterol and reproterol, respectively, with low accumulation in heart and blood. The clearance pathway of both iodo-compounds was through renal and hepatobiliary routes. The selectivity of iodo-compounds to lung was examined by in vivo receptor blocking study. Radioiodinated fenoterol and reproterol are not a blood products and so they are more safer than the currently available 99mTc-MAA, and their lungs uptake is higher than that of the recently discovered 125/123I-IPMPD, 99mTc(CO)5I, 99mTc-DHPM and 125/123I-paroxetine. So, radioiodinated fenoterol and reproterol could be introduced as a new compromising radiopharmaceuticals for lung perfusion scintigraphy more safe than the currently available 99mTc-MAA and more potential than the recently discovered 125/123I-IPMPD, 99mTc(CO)5I, 99mTc-DHPM and 125/123I-paroxetine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13

Similar content being viewed by others

References

  1. PIOPED Investigators (1990) JAMA 263(20):2753–2759

    Article  Google Scholar 

  2. Bajc M, Neilly JB, Miniati M, Schuemichen C, Meignan M, Jonson B (2009) Eur J Nucl Med Mol Imaging 36:1356–1370

    Article  CAS  Google Scholar 

  3. Parker JA, Coleman RE, Grady E, Royal HD, Siegel BA, Stabin MG, Sostman HD, Hilson AJW (2012) J Nucl Med Technol 40(1):57–65

    Article  Google Scholar 

  4. Hofman MS, Beauregard JM, Barber TW, Neels OC, EU P, Hicks RJ (2011) J Nucl Med 52:1513–1519

    Article  CAS  Google Scholar 

  5. Akkas BE, Gokcora N, Atasever T, Yetkin I (2011) J Nucl Med Commun 32(12):1179–1184

    Article  Google Scholar 

  6. Yang G, Wang X, Wang Z, Jiang Y, Fu J (2011) J Clin Nucl Med 36(11):1029–1030

    Article  Google Scholar 

  7. Gu T, Shi H, Xiu Y, Gu Y (2011) J Clin Nucl Med 36(11):e209–e212

    Article  Google Scholar 

  8. Sakr TM (2014) Radiochemistry 56:170–175

    Google Scholar 

  9. Mariano GD, Barbotte E, Basurko C, Comte F, Rossi M (2006) Eur J Nucl Med Mol Imaging 33(9):1048–1054

    Article  Google Scholar 

  10. Nimmo MJ, Merrick MV, Millar AM (1985) J Radiol 58:635–636

    Article  CAS  Google Scholar 

  11. Rowe IF, Sleight PJ, Gaunt JI, Croft DN (1984) Eur J Nucl Med 9:154–156

    Article  CAS  Google Scholar 

  12. Stavngaard T, Sogaard LV, Mortensen J, Hanson LG, Schmiedeskamp J, Berthelsen AK, Dirksen A (2005) Eur J Nucl Med Mol Imaging 32(4):448–457

    Article  Google Scholar 

  13. Wu Y, Kotzer CJ, Makrogiannis S, Logan GA, Haley H, Barnette MS, Sarkar SK (2011) Mol Imaging Biol 13(5):923–929

    Article  Google Scholar 

  14. Ogi S, Gotoh E, Uchiyama M, Fukuda K, Urashima M, Fukumitsu N (2009) Jpn J Radiol 27(1):20–24

    Article  CAS  Google Scholar 

  15. Dugdale DC, Hadjiliadis D (2012) Medline plus. http://www.nlm.nih.gov/medlineplus/ency/article/003828.htm

  16. Miroslavova AE, Gorshkova NI, Lompov AL, Yalfimov AN, Suglobov DN, Ellis BL, Braddock R, Smith A, Prescott MC, Lawson RS, Sharma HL (2009) J Nucl Med Bio 36:73–79

    Article  Google Scholar 

  17. Lobov SA, King DW, Knox KJ, Senden TJ, Stephens RW (2013) Biomaterials 34:1732–1738

    Article  CAS  Google Scholar 

  18. http://medicalcenter.osu.edu/heart/conditions/Pages/Tests/PerfusionLungScan.aspx

  19. Klaus Z, Claudia BS, Jorg P, Joachim K (2009) Annals Nucl Med 23:1–16

    Article  Google Scholar 

  20. Xu JH, Qin JC, Chen WZ, Jiao J, Wang P, Li JF, Zhang Y, Cheng MH (2012) Clin Nucl Med 37(4):377–379

    Article  Google Scholar 

  21. Hunt AP, Frier M, Johnson RA, Berezenko S, Perkins AC (2006) Eur J Pharm Biopharm 62:26–31

    Article  CAS  Google Scholar 

  22. Perkins AC, Frier M (1999) J Nucl Med Commun 20(1):1–3

    Article  CAS  Google Scholar 

  23. Alberto R, Pak JK, Van Staveren D, Mundwiler S, Benny P (2004) Biopolymers 76:324–333

    Article  CAS  Google Scholar 

  24. De K, Chandra S, Sarkar B, Ganguly S, Misra M (2010) J Radioanal Nucl Chem 283:621–628

    Article  CAS  Google Scholar 

  25. Motaleb MA, El-Kolaly MT, Rashed HM, El-Bary A (2012) J Radioanal Nucl Chem 292:629–635

    Article  CAS  Google Scholar 

  26. Helisch A, Schirrmacher E, Thews O, Schirrmacher R, Buchholz HG, Dillenburg W, Hohnemann S, Tillmanns J, Wessler I, Buhl R, Rosch F, Bartenstein P (2005) Eur J Nucl Med Mol Imaging 32(11):1324–1328

    Article  CAS  Google Scholar 

  27. Schirrmacher E, Schirrmacher R, Thews O, Dillenburg W, Helisch A, Wessler I, Buhl R, Hohnemann S, Buchholz HG, Bartenstein P, Machulla HJ, Rosch F (2003) Bio Med Chem Lett 13:2687–2692

    Article  CAS  Google Scholar 

  28. Laurence LB (2011) Goodman and Gilman’s the pharmacological basis of therapeutics, 12th edn. McGraw Hill Professional, New York

    Google Scholar 

  29. Richard AH, Pamela CC (2009) Pharmacology, 4th edn. Lippincott Williams and Wilkin, Baltimore

    Google Scholar 

  30. Beasley R, Pearce N, Crane J, Burgess C (1992) Int Arch Allergy Immunol 99:302–305

    Article  Google Scholar 

  31. Virchow JC (1999) Respiration 66:210–211

    Article  CAS  Google Scholar 

  32. Greenwood N, Earnshaw A (1997) Chemistry of the elements, 2nd edn. Butterworth-Heinemann, Oxford

    Google Scholar 

  33. Amin AM, Soliman SE, El-Aziz HA, Abo El-Enein SA (2013) Inter J Chem 6:1916–9698

    Article  Google Scholar 

  34. Rhodes BA (1984) J Nucl Med 4:281

    Google Scholar 

  35. Saha GB (2011) Fundamental of nuclear pharmacy, 5th edn. Springer, New York

    Google Scholar 

  36. Puttaswamy, Sukhdev A, Shubha JP (2009) J Mol Cat A Chem 310(1–2):24–33

    Article  CAS  Google Scholar 

  37. Shubha JP, Puttaswamy (2009) J Sulfur Chem 30(5):490–499

    Article  CAS  Google Scholar 

  38. Richard RG, Harry H, Jagadeesh RV, Puttaswamy (2001) “e-EROS encyclopedia of reagents for organic synthesis”, John Wiley & Sons, Ltd, Published Online: (2013)

  39. Judah A, Carl DA, John BA (1973) J Chem Soc Perkin Trans 2:595–599

    Google Scholar 

  40. Vallabhajosula S, Nikolopoulou A (2011) Semin Nucl Med 41(5):324–333

    Article  Google Scholar 

  41. Attila V, Sandor N, Zoltan K, Rezso GL, Rosch F (2011) Handbook of nuclear chemistry, 2nd edn. Springer, New York

    Google Scholar 

  42. El-Azony km (2010) J Radioanal Nucl Chem 285(2):315–320

    Article  CAS  Google Scholar 

  43. Tolmachev V, Bruskin A, Sivaev I, Lundqvist H, Sjoberg S (2002) Radiochem Acta 90:229–235

    Article  CAS  Google Scholar 

  44. Abdel-Ghany IY, Moustafa KA, Abdel-Bary HM, Shams El-Din HA (2013) J Radioanal Nucl Chem 295:1273–1281

    Article  CAS  Google Scholar 

  45. Motaleb MA, Moustapha ME, Ibrahim IT (2011) J Radioanal Nucl Chem 289(1):239–245

    Article  CAS  Google Scholar 

  46. Rashed HM, Ibrahim IT, Motaleb MA, Abd El-Bary A (2014) J Radioanal Nucl Chem 300(3):1227–1233

    Article  CAS  Google Scholar 

  47. Kuchar M, Oliveira MC, Gano L, Santos I, Kniess T (2012) Bioorg Med Chem Lett 22:2850–2855

    Article  CAS  Google Scholar 

  48. Georgakopoulos CG, Tsitsimpikou C, Spyridaki MH (1999) J Chromatography B 726:141–148

    Article  CAS  Google Scholar 

  49. Duovent® UDV Product Monograph (November 2012). Boehringer Ingelheim (Canada) Ltd.

Download references

Author information

Authors and Affiliations

  1. Labeled Compound Department, Hot Labs Center, Atomic Energy Authority, P.O. 13759, Cairo, Egypt

    M. M. Swidan, M. A. Motaleb & M. T. El-Kolaly

  2. Radioactive Isotopes and Generator Department, Hot Labs Center, Atomic Energy Authority, P.O. 13759, Cairo, Egypt

    T. M. Sakr

  3. Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Cairo University, P.O. 11562, Cairo, Egypt

    A. Abd El-Bary

Authors
  1. M. M. Swidan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. M. Sakr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Motaleb
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Abd El-Bary
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. T. El-Kolaly
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. M. Sakr.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Swidan, M.M., Sakr, T.M., Motaleb, M.A. et al. Preliminary assessment of radioiodinated fenoterol and reproterol as potential scintigraphic agents for lung imaging. J Radioanal Nucl Chem 303, 531–539 (2015). https://doi.org/10.1007/s10967-014-3328-2

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-014-3328-2

Keywords

Search

Navigation