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Synthesis and preliminary affinity testing of 123I/125I-N-(3-iodophenyl)-2-methylpyrimidine-4,6-diamine as a novel potential lung scintigraphic agent

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Radiochemistry Aims and scope

Abstract

Radioiodinated N-(3-iodophenyl)-2-methylpyrimidine-4,6-diamine (radioiodinated IPMPD), a potential lung scintigraphic agent, was synthesized via direct electrophilic substitution. Factors affecting the radiochemical yield were studied in detail. High radiochemical yield (92.3 ± 2.3%) was reached. The compound is stable in vitro for 24 h. Radioiodinated IPMPD was biologically evaluated in normal Albino mice. The compound demonstrated high lung uptake (21.4 ± 1.7% of injected dose per gram organ at 15 min) and thus shows promise for lung perfusion scintigraphy.

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Authors and Affiliations

  1. Radioactive Isotopes and Generator Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    T. M. Sakr

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  1. T. M. Sakr
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Correspondence to T. M. Sakr.

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Published in Russian in Radiokhimiya, 2014, Vol. 56, No. 2, pp. 170–175.

The text was submitted by the author in English.

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Sakr, T.M. Synthesis and preliminary affinity testing of 123I/125I-N-(3-iodophenyl)-2-methylpyrimidine-4,6-diamine as a novel potential lung scintigraphic agent. Radiochemistry 56, 200–206 (2014). https://doi.org/10.1134/S1066362214020131

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  • DOI: https://doi.org/10.1134/S1066362214020131

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